Parkinson''div-gpt-ad-1450190541376-0''div-gpt-ad-1450190541376-1''s care and often indefinitely.
The researchers also found that such risk increases with the duration of PPI use, even when the drugs are taken at low doses.
The study is published online May 30 in the journal The BMJ.
"" said senior author Ziyad Al-Aly, MD, an assistant professor of medicine at the School of Medicine. He has led several studies associating PPIs to chronic kidney disease and an increased risk of death.
Other researchers independently have linked PPIs to adverse health problems such as dementia, bone fractures, heart disease and pneumonia, among others.
PPIs—sold under brand names such as Prevacid, Prilosec, Nexium and Protonix—bring relief by reducing gastric acid. PPIs are among the most commonly used classes of drugs in the U.S.
For the study, researchers sifted through de-identified medical records in a database maintained by the U.S. Department of Veterans Affairs. Examining medical data acquired from July 2002 to June 2004, the researchers identified 157,625 people—mostly Caucasian men ages 65 and older—who had been newly prescribed PPIs, and 56,842 people who had been newly prescribed another class of acid-suppression drugs known as H2 blockers. They followed the patients—214,467 in total—for up to 10 years.
The researchers found a 17 percent increased risk of death in the PPI group compared with the H2 blocker group. They calculated 45 excess deaths attributable to long-term PPI use per 1,000 people. Death rates for PPIs were 387 per 1,000 people, and death rates for H2 blockers were 342 per 1,000.
"" said Al-Aly, a nephrologist and clinical epidemiologist.
PPI use was associated with deaths caused by cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. Specifically, 15 per 1,000 of the PPI users died from heart disease; four per 1,000 from chronic kidney disease, and two per 1,000 from stomach cancer. Death rates due to cardiovascular disease were 88 among the PPI group and 73 among the H2 blockers group. For stomach cancer, death rates were six in the PPI group and four in the H2 blockers group. Death rates due to chronic kidney disease were eight and four in the PPI and H2 blocker groups, respectively.
Additionally, the study found that more than half of the people taking PPIs did so without a medical need, although the data did not indicate why the patients had been prescribed PPIs. Among this group, PPIs-related deaths were more common, with almost 23 people per 1,000 dying from heart disease, almost five per 1,000 from chronic kidney disease, and three from stomach cancer.
"" Al-Aly said. ""
Heartburn Remedies Cure Your Acid Reflux (🔥 10 Remedies) | Heartburn Remedies Home Remedies Forhow to Heartburn Remedies for The study also found that more than 80 percent of PPI users were on low doses of the prescription drug, or those equivalent to doses offered in over-the-counter versions. "" he said.
The U.S. Food and Drug Administration has expressed interest in data presented by Al-Aly''s research team will continue to study adverse health effects related to PPIs, in particular regarding those at the highest risk.
"" Al-Aly added. ""
Yan Xie et al, Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study, BMJ
(2019). DOI: 10.1136/bmj.l1580
Citation: Heartburn drugs linked to fatal heart and kidney disease, stomach cancer (2019, May 30) retrieved 6 May 2020 from https://medicalxpress.com/news/2019-05-heartburn-drugs-linked-fatal-heart.html
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